Electrophiles against (Skin) Diseases: More Than Nrf2

The skin represents an indispensable barrier between the organism and the environment and is the first line of defense against exogenous insults.The transcription factor NRF2 is a central regulator of cytoprotection and stress resistance.NRF2 is activated in response to oxidative stress by reactive oxygen species (ROS) and electrophiles.These elect

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Percutaneous tricuspid valve replacement in childhood

Percutaneous replacement of the tricuspid valve with a bovine jugular venous valve (melody valve) was successfully undertaken in a 9-year-old boy.The patient had a previous history of bacterial endocarditis of the Melts native tricuspid valve in infancy.Initially, a pericardial patch valve was created, followed by surgical replacement of the valve

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